Designing a CXCL8-hsa chimera as potential immunmodulator of the tumor micro-environment.

ABSTRACT:

Introduction

CXCL8, belonging to inflammatory chemokines, is expressed by various cell types and plays a key role in leukocyte trafficking during infections, inflammatory processes, tissue injury and tumor progression. Chemokines interact not only with G-protein coupled receptors but also with glycosaminoglycans (GAGs), which are polyanionic linear polysaccharides. Chemokine-GAG interactions are critical for creating localized concentration gradients, protecting chemokines from degradation, and maintaining their efficacy in vivo.

Methods

We have previously engineered a CXCL8-based dominant-negative decoy ("PA401") with strongly increased GAG binding affinity combined with complete GPCR knockout, which was originally developed for the treatment of COPD. Here we have op

SUBMITTER: Gerlza T 

PROVIDER: S-EPMC11926544 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature