Pathology and host-pathogen interactions in a golden Syrian hamster model of Nipah virus infection.

ABSTRACT: Nipah virus (NiV) is recognized as one of the key pathogens with pandemic potential. We have recently established a NiV hamster model, which reproduces a highly similar disease to that observed in human cases, including respiratory and neurological signs and lesions. The aims of this study were to describe the microscopic lesions observed in the golden Syrian hamster model after intranasal (IN) and intraperitoneal (IP) inoculation with different doses of the Malaysian strain of NiV; to describe in depth the cell composition of the pulmonary and the brain lesions and the expression of proinflammatory cytokines in-situ using a combination of histopathological techniques including immunohistochemistry (IHC) and in-situ hybridisation (ISH) via RNAscope technique. We also develope

SUBMITTER: Ruedas-Torres I 

PROVIDER: S-EPMC11926554 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature