Systemic Hormonal Contraceptive Use and Rhinitis Among Adult Women: An All of Us Database Analysis.

ABSTRACT:

Objectives

The role of sex hormones in the pathogenesis of allergic and inflammatory conditions such as rhinitis has been receiving increased attention, with evidence supporting an inflammation-modulating role of estrogen and progesterone in the nasal mucosa. However, the specific influence of hormonal contraceptives in rhinitis has been sparsely studied. As such, we sought to investigate the association of systemic hormonal contraceptives with both allergic (AR) and nonallergic rhinitis (NAR) using a national data set of adults in the United States.

Methods

This study was conducted using data from 46,205 female participants aged 20-40 in the All of Us Research Program. Rhinitis diagnoses, systemic hormonal contraceptive use, and covariate data were extracted for all

SUBMITTER: Chiu RG 

PROVIDER: S-EPMC11926567 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature