Integrated clinico-molecular analysis of gastric cancer in European and Latin American populations: LEGACY project.

ABSTRACT:

Background

Gastric cancer (GC) is recognized for intrinsic heterogeneity, although it is similarly approached in Europe and Latin America (LATAM). The LEGACY project aimed to deepen GC molecular understanding through multi-omics analysis in Europe and LATAM GC samples.

Patients and methods

Tumor samples were centrally reviewed for histology, human epidermal growth factor receptor 2 (HER2) expression, and mismatch repair-deficient (dMMR)/microsatellite instability (MSI) status. In addition, we assessed Epstein-Barr virus (EBV) status, programmed death-ligand 1 (PD-L1) combined positive score (CPS), and carried out tissue genomic profiling including tumor mutation burden (TMB) quantification plus targeted transcriptomics for immune microenvironment and cancer cell signaling sc

SUBMITTER: Dienstmann R 

PROVIDER: S-EPMC11926697 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature