Chicken anemia virus inhibits hematopoiesis and development of chicken embryo.

ABSTRACT: Chicken anemia virus (CAV), when primarily transmitted through the vertical route, could result in a significant global prevalence. Specifically, vertical CAV transmission, especially in newly-hatched chicks, may cause anemia and immunosuppression, leading to significant losses in the global poultry industry. Although CAV infection of chick embryos is critical in its vertical transmission, the pathogenicity of CAV in these embryos remains unclear. Herein, CAV-infected chick embryos exhibited a reduced hatchability rate, decreased embryo weight, and anemia. Furthermore, histopathological findings revealed reduced hematopoietic foci in the yolk sac and spleen, as well as pancytopenia and cortical lymphopenia in the bone marrow and thymus, respectively. Additionally, an analysis of the relati

SUBMITTER: Yan T 

PROVIDER: S-EPMC11926702 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature