Prospective planning comparison of magnetic resonance-guided vs. internal target volume-based stereotactic body radiotherapy of hepatic metastases - Which patients do really benefit from an MR-linac?

ABSTRACT:

Purpose/objective

To compare online MR-guided SBRT (MRgRT) of liver metastases with state-of-the-art ITV-based SBRT (ITV-SBRT) and assess which patients benefit most from MRgRT.

Materials and methods

In a prospective randomized trial (MAESTRO study, NCT05027711), patients were randomized to either gated and online adaptive MRgRT or ITV-SBRT if a biologically effective dose (BED₁₀) of 100 Gy was feasible with ITV-SBRT. Otherwise, patients were treated with MRgRT. In this subgroup analysis of 20 patients, a dosimetric comparison of MRgRT and ITV-SBRT plans was performed. Tumor control and normal tissue complication probabilities were calculated.

Results

In 40 % of all patients, MRgRT enabled SBRT with less fractions and/or higher prescription BED₁₀

SUBMITTER: Hoegen-Saßmannshausen P 

PROVIDER: S-EPMC11926716 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature