Initial nucleation of nanodroplets in viscoelastic tissue driven by ultrasound: A theoretical simulation.

ABSTRACT: Phase-change nanodroplets hold promising potential for theranostic applications in tumor tissue. However, the initial nucleation of nanodroplets in tissue-a critical stage for subsequent vapor bubble dynamics and theranostic efficacy-remains unexplored. This work, accounting for nanodroplets and tissue as compressible mediums, was represented by two springs in series: one for nanodroplet compressibility and the other for tissue elasticity. By analyzing the linear relationship between internal nanodroplet pressure and volume changes in nanodroplets and tissue, the classical nucleation theory (CNT) was modified to describe the initial nucleation of perfluoropentane (PFP) nanodroplets in tissue. The key nucleation conditions, such as the stable critical radius and initial nucleation threshold

SUBMITTER: Feng K 

PROVIDER: S-EPMC11926720 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature