Cytotoxicity of Amyloid β1-42 Fibrils to Brain Immune Cells.

ABSTRACT: Alzheimer's disease (AD) is a progressive pathology that is linked to abrupt aggregation of amyloid β_1-42 (Aβ_1-42) peptide in the central nervous system. Aβ_1-42 aggregation yields amyloid oligomers and fibrils, toxic protein aggregates that cause progressive neuronal degeneration in the frontal lobe of the brain. Although neurons remain the focus of AD for decades, a growing body of evidence suggests that the degeneration of immune cells in the brain can be the major cause of AD. However, the extent to which Aβ_1-42 aggregates are toxic to the major classes of immune cells in the brain remains unclear. In the current study, we examine the cytotoxic effects of Aβ_1-42 fibrils on macrophages, dendritic cells, and microglia. These cells pla

SUBMITTER: Matveyenka M 

PROVIDER: S-EPMC11926782 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature