Stacking Interactions in Indomethacin Solid-State Forms.

ABSTRACT: Stacked structures with strong dispersion forces between stack neighbors often lead to anisotropic crystal growth and needlelike morphologies. The crystal structures of a new cocrystal and a molecular salt of indomethacin (IND) are reported: IND·MOA and IND·POBA·0.5H₂O (MOA = p-methoxyaniline, POBA = 4-phenoxybenzylamine). In both structures, the IND and coformer molecules/ions are stacked and IND adopts the unusual conformation found in the α-polymorph of pure IND, resulting in a relatively short distance of about 3 Å between the methyl group and the C1'-atom of the chlorophenyl ring. While IND·MOA and IND·POBA·0.5H₂O both crystallize as needles like α-IND, the weaker stacking interactions of the coformer in the IND·MOA cocrystal lead to shorter and thicker ne

SUBMITTER: Fereidouni N 

PROVIDER: S-EPMC11926784 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature