Effect of Lipidation on the Structure, Oligomerization, and Aggregation of Glucagon-like Peptide 1.

ABSTRACT: Lipidated analogues of glucagon-like peptide 1 (GLP-1) have gained enormous attention as long-acting peptide therapeutics for type 2 diabetes and also antiobesity treatment. Commercially available therapeutic lipidated GLP-1 analogues, semaglutide and liraglutide, have the great advantage of prolonged half-lives in vivo of hours and days instead of minutes as is the case for native GLP-1. A crucial factor in the development of novel lipidated therapeutic peptides is their physical stability, which greatly influences manufacturing and drug product development. This work provides a systematic study of the solubility, structure, oligomerization, and long-term stability of five different lipidated analogues of GLP-1, varying in the position of the lipidation site and the nature of lipid

SUBMITTER: Prada Brichtova E 

PROVIDER: S-EPMC11926786 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature