Direct Imaging of Chirality Transfer Induced by Glycosidic Bond Stereochemistry in Carbohydrate Self-Assemblies.

ABSTRACT: Carbohydrates, essential biological building blocks, exhibit functional mechanisms tied to their intricate stereochemistry. Subtle stereochemical differences, such as those between the anomers maltose and cellobiose, lead to distinct properties due to their differing glycosidic bonds; the former is digestible by humans, while the latter is not. This underscores the importance of precise structural determination of individual carbohydrate molecules for deeper functional insights. However, their structural complexity and conformational flexibility, combined with the high spatial resolution needed, have hindered direct imaging of carbohydrate stereochemistry. Here, we employ noncontact atomic force microscopy integrated with a data-efficient, multifidelity structure search approach accelerate

SUBMITTER: Cai S 

PROVIDER: S-EPMC11926875 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature