Mechanistic Insights into the Membrane Permeabilization Activity of Antimicrobial Prenylated Isoflavonoids: A Comparative Study of Glabridin, Wighteone, and Lupiwighteone.

ABSTRACT: Prenylated isoflavonoids have shown remarkable antimicrobial activity. Previous studies showed that the antimicrobial compounds glabridin and wighteone induced membrane permeabilization in microbial cells. Other compounds, such as lupiwighteone, showed no antimicrobial activity. In this study, the permeabilization efficacy and interaction with lipid bilayers of glabridin, wighteone, and lupiwighteone were assessed in vitro and in silico using model membranes. Permeabilization of liposomes by glabridin and wighteone confirmed the lipid bilayer as the primary target. Notably, lupiwighteone did not induce the permeabilization of liposomes. Molecular dynamics (MD) simulations were used to study the interaction of these compounds with phospholipid membranes. The calculated potenti

SUBMITTER: Bombelli A 

PROVIDER: S-EPMC11926876 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature