Seasonal variations in circulating endocannabinoidome mediators and gut microbiota composition in humans.

ABSTRACT:

Background

The human gut microbiome-endocannabinoidome axis is crucial for several homeostatic processes, including inflammation and energy metabolism, and is influenced by many endogenous and exogenous factors, such as dietary habits. Changes in the gut microbiome in response to seasonal variations were previously reported and tentatively attributed to shifts in dietary patterns. However, there is a need for longitudinal studies in industrialized populations to comprehensively explore seasonal variations independently of lifestyle confounding factors.

Objective

To investigate the longitudinal effects of seasonal variations on the composition of the gut microbiome and the circulating levels of endocannabinoidome mediators in humans, while elucidating the contributing factors

SUBMITTER: Castonguay-Paradis S 

PROVIDER: S-EPMC11926903 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature