Retrograde Amnesia in LGI1 and CASPR2 Limbic Encephalitis: Two Case Reports and a Systematic Literature Review.

ABSTRACT:

Background

Both anterograde and retrograde amnesia can typically co-occur in limbic autoimmune encephalitis (LAE), including the forms associated with antibodies to CASPR2/LGI1, two protein complexed with the voltage-gated potassium channel (VGKC). However, isolated retrograde amnesia is very rare, and it has never been described in LAE.

Methods

We report two patients with CASPR2 LAE who showed isolated retrograde amnesia, without other significant cognitive impairments. A systematic literature review was performed in accordance with the PRISMA guidelines on patients with LAE, antibodies to the VGKC complex (including LGI1, CASPR2, or the VGKC), and memory impairment.

Results

We identified 467 patients from 29 studies. Fourteen/467 had retrograde amnesia (2.9%), which

SUBMITTER: Antonio M 

PROVIDER: S-EPMC11927019 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature