Associations of genetic factors with vascular diabetes complications: an umbrella review.

ABSTRACT:

Background

To comprehensively assess evidence from published systematic review and meta-analyses (SRMAs) on the genetics of vascular diabetes complications.

Methods

A systematic literature search conducted in Medline and Embase identified 63 non-overlapping SRMAs. We re-conducted meta-analyses to compare diabetes with and without complications using multiple genetic models; evaluated associations using Venice criteria and Bayesian false-discovery probability (BFDP); and graded as highly credible, credible, and not credible. We also contrasted highly credible and credible associations to recent genome-wide association studies (GWASs).

Results

Highly credible evidence was discovered for single nucleotide polymorphisms (SNPs) rs1024611 at MCP-1 gene and SNP rs3025039 at

SUBMITTER: Zhou X 

PROVIDER: S-EPMC11927039 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature