Multiple primary malignancies and gut microbiome.

ABSTRACT:

Background

Multiple primary malignancies (MPM) are two or more independent primary malignancies. Recently, the relationship between microbiome and various tumors has been gradually focused on.

Objective

To describe the relationship between MPM patients (MPMs) and gut microbiome.

Methods

A total of 27 MPMs, 30 colorectal cancer patients (CRCs), and 30 healthy individuals were included to obtain metagenomic sequencing data. The knowledge graphs of gut bacteria and enteroviruses were plotted based on metagenomics. Wilcoxon rank-sum test was used to screen the characteristic gut microbiome.

Results

The knowledge graph of gut microbiome in MPM patients was plotted. A total of 26 different gut bacteria, including Dialister, Fecalibacterium and Mediterraneibacter, wer

SUBMITTER: Wu Y 

PROVIDER: S-EPMC11927136 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature