Exploring the protective effect of metformin against sarcopenia: insights from cohort studies and genetics.

ABSTRACT:

Background

The impact of metformin on sarcopenia remains uncertain. This study aimed to investigate whether metformin influences sarcopenia risk and evaluate the effects of potential drug targets on sarcopenia traits.

Methods

We analyzed data from the National Health and Nutrition Examination Survey (NHANES) (n = 3549) to assess the association between metformin use and sarcopenia risk in elderly patients with type 2 diabetes. Mendelian randomization (MR) analysis using genome-wide association studies (GWAS) from UK Biobank (n = 1,366,167) and FinnGen (n = 218,007), with expression quantitative trait loci (eQTL) as instrumental variables, examined the causal effect of metformin-related targets on sarcopenia traits, while molecular docking explored the interaction between met

SUBMITTER: Hu Y 

PROVIDER: S-EPMC11927167 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature