Impact of effective connectivity within the Papez circuit on episodic memory: moderation by perivascular space function.

ABSTRACT:

Background and objectives

The formation and retrieval of episodic memory is dependent on the coordinated activity of multiple brain regions and neural networks, with the Papez circuit playing a critical role in this process. Recently, the role of the perivascular space (PVS) in cognitive function has garnered increasing attention. However, the role of PVS function between neural circuits and cognitive function in amnestic mild cognitive impairment (aMCI) patients remains unknown. Therefore, this study aims to (1) investigate alterations in the effective connectivity of the Papez circuit and PVS function in patients with aMCI and (2) explore the role of PVS function between the effective connectivity of the Papez circuit and episodic memory.

Methods

Sixty participants, all of

SUBMITTER: Li LL 

PROVIDER: S-EPMC11927174 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature