Highly expressed GCN1 is associated with cancer progression and poor prognosis in hepatocellular carcinoma patients.

ABSTRACT:

Background

General control non-derepressible protein 1 (GCN1), a ribosome-binding protein, has been implicated in the development and progression of multiple cancers. However, the potential role of GCN1 in hepatocellular carcinoma (HCC) has not yet been investigated.

Methods

The expression of GCN1 in HCC was analyzed using multiple databases. Bioinformatics analysis was employed to investigate the correlation of GCN1 expression with clinical significance and immune infiltration in HCC. Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis, gene set enrichment analysis (GSEA), and in vitro experiments were conducted to study the function and potential mechanisms of GCN1 in HCC.

Results

GCN1 was significantly upregulated in HCC, which was associated with wo

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC11927180 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature