Metabolomic profiling reveals early biomarkers of gestational diabetes mellitus and associated hepatic steatosis.

ABSTRACT:

Background

This study aims to identify early metabolomic biomarkers of gestational diabetes mellitus (GDM) and evaluate their association with hepatic steatosis.

Methods

We compared maternal serum metabolomic profiles between women who developed GDM (n = 118) and matched controls (n = 118) during the first (10-14 gestational weeks) and second (24-28 gestational weeks) trimesters using ultra-performance liquid chromatography coupled with mass spectrometry. Mediation analysis was performed to evaluate the mediating role of metabolic dysfunction-associated steatotic liver disease (MASLD) in the relationship between metabolites and subsequent development of GDM. A refined prediction model was developed to predict GDM using established clinical factors and selected metabolites.

SUBMITTER: Jung Y 

PROVIDER: S-EPMC11927189 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature