Perinatal hypoxia-mediated neurodevelopment abnormalities in congenital heart disease mouse model.

ABSTRACT:

Background

Cyanotic congenital heart disease (CHD) in children has been associated with neurodevelopmental abnormalities, although the underlying mechanisms remain largely unknown. Multiple factors are likely involved in this process. This research aims to explore the potential effects of hypoxia and vascular system-derived factors in neurodevelopmental outcomes in offspring.

Methods

Mouse aorta endothelial cells (MEC) and amygdala neurons were isolated to investigate the effects of hypoxia on pro-inflammatory cytokine release, gene expression, redox balance, mitochondrial function, and epigenetic modifications. A CHD mouse model was established to evaluate the impact of perinatal hypoxia on fetal brain development. Estrogen receptor β (ERβ) expression in endothelial cells w

SUBMITTER: Chen R 

PROVIDER: S-EPMC11927194 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature