MAIT cell deficiency exacerbates neuroinflammation in P301S human tau transgenic mice.

ABSTRACT:

Background

The role of immune cells in neurodegeneration remains incompletely understood. Accumulation of misfolded tau proteins is a hallmark of neurodegenerative diseases. Our recent study revealed the presence of mucosal-associated invariant T (MAIT) cells in the meninges, where they express antioxidant molecules to maintain meningeal barrier integrity. However, the role of MAIT cells in tau-related neuroinflammation and neurodegeneration remains unknown.

Methods

Flow cytometry analysis was performed to examine MAIT cells in human Tau P301S transgenic mice. Tau pathology, hippocampus atrophy, meningeal integrity, and microglial gene expression were examined in Mr1^-/- P301S mice that lacked MAIT cells and control P301S transgenic mice, as well as Mr1^-/-

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC11927249 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature