Influence of alloplastic materials, biologics, and their combinations, along with defect characteristics, on short-term intrabony defect surgical treatment outcomes: a systematic review and network meta-analysis.

ABSTRACT:

Background

Treating periodontal intrabony defects remains challenging, alloplast materials and biologics are increasingly utilized to improve regeneration outcomes. However, comparative efficacy on alloplast materials remains limited. This study aimed to evaluate the effectiveness of alloplastic materials, both alone and combined with biologics, in treating periodontal defects.

Methods

A systematic search of PubMed, Scopus, and CENTRAL identified 74 eligible randomized controlled trials. Meta-analysis assessed data heterogeneity based on defect depth and morphology, classifying defects by wall configuration. Network meta-analysis compared clinical attachment level (CAL) gain, probing depth (PD) reduction, and radiographic linear bone (RLB) gain up to 12 months. Risk of bias

SUBMITTER: Rattanpornsompong K 

PROVIDER: S-EPMC11927257 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature