MEOX2 mediates cisplatin resistance in ovarian cancer via E2F target and DNA repair pathways.

ABSTRACT: Ovarian cancer (OV) is a leading cause of cancer-related mortality among women worldwide. Despite the success of platinum-based chemotherapy in treating OV, the emergence of cisplatin resistance has significantly compromised its therapeutic efficacy. Therefore, understanding the mechanisms underlying cisplatin resistance and its molecular regulation is crucial for improving patient outcomes. This study, MEOX2 was identified as a key gene significantly associated with prognosis and cisplatin resistance in OV through bioinformatics analysis. Its expression level and biological functions were validated using online databases, tissue microarrays, and cellular experiments. The results demonstrated that high MEOX2 expression was closely associated with poor survival outcomes in OV patients, whil

SUBMITTER: Wang F 

PROVIDER: S-EPMC11927352 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature