Protein tyrosine phosphatase delta is a STAT3-phosphatase and suppressor of metabolic liver disease.

ABSTRACT:

Abstract

Objective

Impaired hepatic expression of protein tyrosine phosphatase delta (PTPRD) is associated with increased STAT3 transcriptional activity and reduced survival from hepatocellular carcinoma in patients with chronic hepatitis C virus infection. However, the PTPRD-expressing hepatic cell types, signalling pathways responsive to PTPRD and their role in non-viral liver disease are largely unknown.

Methods

We studied PTPRD expression in single-cell and bulk liver transcriptomic data from mice and humans, and established a Ptprd-deficient mouse model for metabolic dysfunction-associated steatohepatitis (MASH). Identified pathways were validated by perturbation studies in human hepatocytes and PTPRD substrates by pull-down assays. T

SUBMITTER: Roca Suarez AA 

PROVIDER: S-EPMC11927410 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature