Cyclin E1 overexpression triggers interferon signaling and is associated with antitumor immunity in breast cancer.

ABSTRACT:

Background

Cyclin E1 overexpression drives oncogenesis in several cancers through deregulation of DNA replication and induction of genomic instability, which may potentially trigger immune signaling via cytoplasmic DNA. However, the effects of cyclin E1 overexpression on tumor immunity and its effects on the response to immune checkpoint inhibitors remain largely unclear.

Methods

Tissue microarrays and clinical outcomes of 398 patients with breast cancer were analyzed to explore the correlation between cyclin E1 expression, patient survival, and immune cell infiltration using immunohistochemistry. Genomic data from publicly available data sets and three clinical trials evaluating immunotherapy were assessed to measure the impact of cyclin E1 expression on the immune cells in

SUBMITTER: Yu S 

PROVIDER: S-EPMC11927439 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature