Mannose reduces fructose metabolism and reverses MASH in human liver slices and murine models in vivo.

ABSTRACT:

Background

Fibrosis drives liver-related mortality in metabolic dysfunction-associated steatohepatitis (MASH), yet we have limited medical therapies to target MASH-fibrosis progression. Here we report that mannose, a simple sugar, attenuates MASH steatosis and fibrosis in 2 robust murine models and human liver slices.

Methods

The well-validated fat-and-tumor MASH murine model for liver steatosis and fibrosis was employed. Mannose was supplied in the drinking water at the start ("Prevention" group) or at week 6 of the 12-week MASH regimen ("Therapy" group). The in vivo antifibrotic effects of mannose supplementation were tested in a second model of carbon tetrachloride (CCl4)-induced liver fibrosis. A quantitative and automated digital pathology approach was used to comprehen

SUBMITTER: Hong JG 

PROVIDER: S-EPMC11927666 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature