Biochemical and biophysical characterization of inositol-tetrakisphosphate 1-kinase inhibitors.

ABSTRACT: Inositol phosphates (IPs) and inositol pyrophosphate play critical roles in many biological processes such as signaling molecules in pathways responsible for cellular functions involved in growth and maintenance. The biosynthesis of IPs is carried out by a family of inositol phosphate kinases. In mammals, Inositol tetrakisphosphate kinase-1 (ITPK1) phosphorylates inositol-1,3,4-trisphosphate (Ins(1,3,4)P₃) and inositol-3,4,5,6-tetrakisphosphate (IP₄), generating inositol-1,3,4,5,6-pentakisphosphate (IP₅), which can be further phosphorylated to become inositol hexakisphosphate (IP₆). ITPK1 also possesses phosphatase activity that can convert IP₅ back to IP₄; therefore, ITPK1 may serve as a regulatory step in IP₆ pr

SUBMITTER: Ng MY 

PROVIDER: S-EPMC11927698 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature