Causal Relationship Between Psoriasis and Bullous Pemphigoid: A Mendelian Randomization Analysis.

ABSTRACT:

Introduction

Psoriasis and bullous pemphigoid (BP) are the two major types of immune-mediated inflammatory skin diseases. Studies have reported the association between psoriasis and BP; however, no studies have reported whether a causal relationship exists between these two skin diseases.

Objectives

In order to explore the causal relationship between psoriasis and BP, we performed a bidirectional two-sample Mendelian randomization (MR) study.

Methods

Genome-wide association study (GWAS) data related to psoriasis and BP were collected. The inverse-variance weighted (IVW) method was primarily applied for our MR analysis; MR-Egger, weighted median, simple mode, and weighted mode methods were also used. Heterogeneity, horizontal pleiotropy, and potential outliers were ass

SUBMITTER: Wang X 

PROVIDER: S-EPMC11928123 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature