Alcohol consumption and childhood trauma impact serum immunoglobulin levels in patients with alcohol use disorder.

ABSTRACT:

Background

Alcohol Use Disorder (AUD) and childhood trauma both have detrimental effects on immune regulation. Immunoglobulins, key biomarkers of the adaptive immune system, may be selectively targeted by heavy alcohol consumption as well as childhood trauma. In this study, we investigated the relationship between alcohol drinking behavior, history of childhood trauma, and circulating levels of immunoglobulin A (IgA), immunoglobulin G (IgG), and immunoglobulin M (IgM) in individuals with AUD.

Methods

Using linear regression, multiple variables, drinks per drinking day and childhood trauma questionnaire (CTQ) score, were evaluated in relation to immunoglobulin levels. All participants (N = 445) were treatment-seeking and admitted to the National Institutes of Health Clinical

SUBMITTER: Abshire KM 

PROVIDER: S-EPMC11928251 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature