Evaluation of fibroinflammatory activity in thyroid eye disease using [¹⁸F]AlF-NOTA-FAPI-04 PET/CT: A prospective study.

ABSTRACT:

Purpose

This study evaluates the value of [¹⁸F]AlF-NOTA-FAPI-04PET/CT in assessing the disease activity of thyroid eye disease (TED).

Methods

Twenty-three TED patients and ten healthy controls were prospectively recruited and underwent [¹⁸F]AlF-NOTA-FAPI-04 PET/CT scans. TED eyes were classified by Clinical Activity Score (CAS) as active (CAS +) or inactive (CAS-). PET analysis included qualitative and quantitative evaluations. Qualitative analysis categorized TED eyes as positive (FAPI +) or negative (FAPI-), while quantitative analysis including SUVmax and target-to-backgroud ratio (TBR) of each extraocular muscle (EOM). Pathological assessment of 16 EOM samples from 15 TED eyes was used as a gold standard to evaluate the diagnostic accuracy of CAS-dr

SUBMITTER: Li H 

PROVIDER: S-EPMC11928422 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature