Three-dimensional spatial localization and volume estimation of prostate tumors using ¹⁸F-PSMA-1007 PET/CT versus multiparametric MRI.

ABSTRACT:

Purpose

Fluorine-18 prostate-specific membrane antigen-1007 positron emission tomography/computed tomography (¹⁸F-PSMA-1007 PET/CT) has been shown to be superior to multiparametric magnetic resonance imaging (MRI) for the locoregional staging of intermediate-risk and high-risk prostate tumors. This study aims to evaluate whether it is also superior in estimating tumor parameters, such as three-dimensional spatial localization and volume.

Methods

134 participants underwent ¹⁸F-PSMA-1007 PET/CT and MRI prior to radical prostatectomy as part of the validating paired-cohort Next Generation Trial (NCT05141760). MRI, ¹⁸F-PSMA-1007 PET/CT, and final pathology were independently assessed by blinded radiologists, nuclear medicine physicians, and patho

SUBMITTER: Huang G 

PROVIDER: S-EPMC11928431 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature