Synthesis, characterization and in silico studies of novel multifunctional imidazole-thiazole hybrids with potent antimicrobial and anticancer properties.

ABSTRACT: Treating infections remains a significant challenge, driving the ongoing pursuit of novel drug candidates. Heterocyclic compounds, such as those containing imidazole and thiazole rings, are well-known for their diverse therapeutic and pharmaceutical applications. In this study, we designed, synthesized, and characterized a series of six novel compounds incorporating these two five-membered rings. The synthesis involved the reaction of different phenacyl bromides with imidazole-hydrazinecarbothioamide to produce imidazole-thiazole hybrid derivatives, which were confirmed through IR, ¹H NMR, ¹³C NMR, and mass spectrometry analyses. The antimicrobial activities of the derivatives were evaluated against three bacterial strains and one fungal strain using the serial diluti

SUBMITTER: Dwarakanath D 

PROVIDER: S-EPMC11928448 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature