Genome wide interaction study of genetic variants associated with lung function decline.

ABSTRACT: Some genetic variants are associated with lung function decline and chronic obstructive pulmonary disease (COPD), but functional studies are necessary to confirm causality. We investigated the genetic susceptibility-associated lung function decline with or without COPD, using data from a community-based cohort (N = 8554). A genome-wide interaction study was conducted to identify the association between genetic variants and pulmonary function, and the way variants relate to lung impairment in accordance with smoking status and amount was examined. We further used a linear mixed model to examine the association and interaction to time effect. We found annual mean FEV₁ declines of 41.7 mL for men and 33.4 mL for women, and the annual rate of decline in FEV₁ was the faste

SUBMITTER: Kim CY 

PROVIDER: S-EPMC11928451 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature