Preliminary feasibility study on DTI to assess the early brain injury in germinal matrix-intraventricular hemorrhage rats.

ABSTRACT: To evaluate the feasibility and efficacy of diffusion tensor imaging (DTI) for detecting early brain microstructure alterations in germinal matrix-intraventricular hemorrhage (GMH-IVH) rat model. This study used a postnatal day 5 (PND 5) rat model of GMH-IVH. T2-weighted imaging and DTI were performed during acute (6 h and 24 h) and subacute (3d and 7d) phases after GMH-IVH. Four DTI parameters including fractional anisotropy (FA), mean diffusion (MD), axial diffusion (AD) and radial diffusion (RD) were collected in 9 specific brain regions to assess the brain microstructure alterations. Early and long-term neurological function tests were evaluated. Transcriptome sequencing analysis was also performed to investigate possible underlying mechanisms. Regional abnormalities after GMH-IVH were

SUBMITTER: Qin C 

PROVIDER: S-EPMC11928497 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature