A multicenter retrospective study evaluating the effect of proton pump inhibitors on adjuvant tegafur-uracil/leucovorin efficacy for stage II-III colorectal cancer.

ABSTRACT: We hypothesized that there is reduced efficacy of fluorinated pyrimidines, such as capecitabine, caused by low active folic acid levels induced by vitamin B₁₂ deficiency, due to proton pump inhibitors (PPIs), and that this can be recovered by the administration of leucovorin (LV). Thus, we retrospectively analyzed the effects of PPIs on adjuvant tegafur-uracil (UFT) plus LV for stage II/III colorectal cancer (CRC). Patients newly diagnosed with stage II/III CRC who underwent curative surgery and received adjuvant UFT/LV therapy between January 2013 and June 2018 were included. The primary endpoint was the difference in relapse-free survival (RFS) between the PPI and non-PPI groups. Data from 396 eligible patients were evaluated, 84 of whom received PPIs. There were 93 relapse ev

SUBMITTER: Takahashi M 

PROVIDER: S-EPMC11928574 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature