Whole-body visualization of SARS-CoV-2 biodistribution in vivo by immunoPET imaging in non-human primates.

ABSTRACT: The COVID-19 pandemic has caused at least 780 million cases globally. While available treatments and vaccines have reduced the mortality rate, spread and evolution of the virus are ongoing processes. Despite extensive research, the long-term impact of SARS-CoV-2 infection is still poorly understood and requires further investigation. Routine analysis provides limited access to the tissues of patients, necessitating alternative approaches to investigate viral dissemination in the organism. We address this issue by implementing a whole-body in vivo imaging strategy to longitudinally assess the biodistribution of SARS-CoV-2. We demonstrate in a COVID-19 non-human primate model that a single injection of radiolabeled [⁸⁹Zr]COVA1-27-DFO human monoclonal antibody targeting a preserved

SUBMITTER: Detrille A 

PROVIDER: S-EPMC11928647 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature