Influence of betel nut chewing on oral microbiome in Papua New Guinea.

ABSTRACT:

Background and objectives

For thousands of years, betel nut has been used as a psychoactive agent in Asian and Oceanian populations. Betel nut chewing was associated with the alteration of human oral microbiome and with diseases such as oral cancer and periodontitis, but only in populations of Asian cultural background. We studied the influence of betel nut chewing on the oral microbiome in Papua New Guinea, where half of the population uses betel nut and the prevalence of these diseases is one of the highest in the world.

Methodology

We characterized the oral microbiomes of 100 Papua New Guineans. We defined two cohorts of betel chewers (n = 50) and non-chewers (n = 50) based on a genetic approach to identify the presence of betel nut in saliva. We statistical

SUBMITTER: Brucato N 

PROVIDER: S-EPMC11928724 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature