Association between the Triglyceride-glucose index and fragility fractures among US adults: insights from NHANES.

ABSTRACT:

Background

The triglyceride-glucose (TyG) index, a recognized marker for insulin resistance, holds potential implications for skeletal health. However, its relationship with fragility fractures remains uncertain. We aimed to elucidate the association between the TyG index and fragility fractures in the general US population.

Methods

Cross-sectional data of 25,082 participants were obtained from the National Health and Nutrition Examination Survey. The association between the TyG index and fragility fractures was investigated using univariate and weighted multivariate logistic regression as well as restricted cubic spline (RCS) regression models. The least absolute shrinkage and selection operator regression with ten-fold cross-validation was employed to identify key variable

SUBMITTER: Lou Y 

PROVIDER: S-EPMC11929254 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature