Expansion and pathogenic activation of skeletal muscle-resident macrophages in <i>mdx^5cv/Ccr2^-/-</i> mice.

ABSTRACT: Infiltrating macrophages contribute to muscle dystrophic changes in Duchenne muscular dystrophy (DMD). In a DMD mouse model, mdx^5cv mice, CC chemokine receptor type 2 (CCR2) deficiency diminishes Ly6C^hi macrophage infiltration by blocking blood Ly6C^hi inflammatory monocyte recruitment. This is accompanied by transient improvement of muscle damage, fibrosis, and regeneration. The benefit, however, is lost after the expansion of intramuscular Ly6C^lo macrophages. To address the mechanisms underlying the Ly6C^lo macrophage expansion, we compared mdx^5cv/Nur77^-/- and mdx^5cv/Ccr2^-/-/Nur7^-/- mice with mdx^5cv and mdx^5cv/Ccr2^-/-<

SUBMITTER: Wang Y 

PROVIDER: S-EPMC11929395 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature