The reuniens thalamus recruits recurrent excitation in the medial prefrontal cortex.

ABSTRACT: The medial prefrontal cortex (mPFC) and hippocampus are critical for memory retrieval, decision making, and emotional regulation. While ventral CA1 (vCA1) shows direct and reciprocal connections with mPFC, dorsal CA1 (dCA1) forms indirect pathways to mPFC, notably via the thalamic reuniens nucleus (Re). Neuroanatomical tracing has documented structural connectivity of this indirect pathway through Re however, its functional operation is largely unexplored. Here, we used in vivo and in vitro electrophysiology along with optogenetics to address this question. Whole-cell patch-clamp recordings in acute mouse brain slices revealed both monosynaptic excitatory responses and disynaptic feedforward inhibition at Re-mPFC synapses. However, we also identified a prolonged excitation of mPFC by Re. T

SUBMITTER: Vantomme G 

PROVIDER: S-EPMC11929439 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature