A mechanistic basis for genetic assimilation in natural fly populations.

ABSTRACT: Genetic assimilation is a process by which a trait originally driven by the environment becomes independent of the initial cue and is expressed constitutively in a population. More than seven decades have passed since Waddington's pioneering demonstration of the acquisition of morphological traits through genetic assimilation, but the underlying mechanism remains unknown. Here, we address this gap by performing combined genomic analyses of Waddington's genetic assimilation experiments using the ectopic veins (EV) phenocopy in Drosophila as a model. Our study reveals the assimilation of EV in both outbred and inbred fly natural populations, despite their limited genetic diversity. We identified key changes in the expression of developmental genes and pinpointed selected alleles invol

SUBMITTER: Sabaris G 

PROVIDER: S-EPMC11929479 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature