Integrative spatiotemporal modeling of biomolecular processes: Application to the assembly of the nuclear pore complex.

ABSTRACT: Dynamic processes involving biomolecules are essential for the function of the cell. Here, we introduce an integrative method for computing models of these processes based on multiple heterogeneous sources of information, including time-resolved experimental data and physical models of dynamic processes. First, for each time point, a set of coarse models of compositional and structural heterogeneity is computed (heterogeneity models). Second, for each heterogeneity model, a set of static integrative structure models is computed (a snapshot model). Finally, these snapshot models are selected and connected into a series of trajectories that optimize the likelihood of both the snapshot models and transitions between them (a trajectory model). The method is demonstrated by application to the a

SUBMITTER: Latham AP 

PROVIDER: S-EPMC11929490 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature