TGF-β-mediated activation of fibroblasts in cervical cancer: implications for tumor microenvironment and prognosis.

ABSTRACT:

Background

Cervical cancer (CC) is a prevalent female malignancy strongly influenced by the tumor microenvironment (TME). This study focuses on the role of TGF-β signaling in cancer-associated fibroblasts (CAFs) and its interaction with immune cells, aiming to elucidate its impact on CC progression.

Methods

The TME of CC patients was analyzed using scRNA-seq data and we identified the major cell types in the TME with a focus on the activation of the TGF-β signaling pathway in fibroblasts. Gene modules related to the TGF-β signaling pathway were identified by Weighted correlation network analysis (WGCNA). Using The Cancer Genome Atlas Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA-CESC) dataset, a prognostic gene model was constructed by univariate Cox

SUBMITTER: Qu H 

PROVIDER: S-EPMC11929507 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature