Sensorimotor Behavior in Individuals With Autism Spectrum Disorder and Their Unaffected Biological Parents.

ABSTRACT: Sensorimotor impairments are common in autism spectrum disorder (ASD) and evident in unaffected first-degree relatives, suggesting that they may serve as endophenotypes associated with inherited autism likelihood. We tested the familiality of sensorimotor impairments in autism across multiple motor behaviors and effector systems and in relation to parental broader autism phenotypic (BAP) characteristics. Fifty-seven autistic individuals (probands), 109 parents, and 89 neurotypical control participants completed tests of manual motor and oculomotor control. Sensorimotor tests varied in their involvement of rapid, feedforward control and sustained, sensory feedback control processes. Subgroup analyses compared families with at least one parent showing BAP traits (BAP+) and those in which nei

SUBMITTER: Bojanek EK 

PROVIDER: S-EPMC11929603 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature