Lower cytoplasmic expression of DDIT4 is associated with poor prognosis in gastric cancer patients.

ABSTRACT:

Introduction

DNA damage-inducible transcript 4 (DDIT4), also known as Redd1, Dig2, and RTP801 was identified to be upregulated in response to a variety of cellular stresses, including DNA damage, endoplasmic reticulum stress, and energy stress. Several studies have discovered that dysregulation of DDIT4 involved in various cancers with paradoxical expression and roles. Hence, this study was designed to investigate the clinical significance and prognostic value of DDIT4 in different subtypes of gastric cancer (GC).

Materials and methods

To evaluate the expression pattern of DDIT4 in GC tissues as well as adjacent normal tissue, we utilized immunohistochemistry on tissue microarray (TMA) slides.

Results

Our findings revealed that nuclear expression of DDIT4 was higher i

SUBMITTER: Dehghan Manshadi M 

PROVIDER: S-EPMC11929655 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature