Serum metabolomic analysis in patients with Hashimoto's thyroiditis positive for TgAb or TPOAb: a preliminary study.

ABSTRACT: Hashimoto's thyroiditis (HT) is a prevalent autoimmune disorder, yet the metabolic abnormalities associated with HT and their relationship to antibody positivity remain poorly understood. This study aimed to characterize the distinct metabolic profiles associated with thyroid peroxidase antibody (TPOAb) and thyroglobulin antibody (TgAb) positivity in female patients with HT. Serum metabolomic analysis was performed on 14 TPOAb-positive patients, 4 TgAb-positive patients, and 14 sex-matched healthy controls, evaluating a total of 225 metabolites. Partial least squares discriminant analysis (PLS-DA) revealed significant metabolic differences among the groups, identifying 36 key metabolites. Of these, 13 metabolites showed significant differences between the TPOAb-positive group and healthy c

SUBMITTER: Luo T 

PROVIDER: S-EPMC11929742 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature