Unraveling HIV-1 transmission patterns through molecular surveillance in a hotspot in Yunnan Province, China.

ABSTRACT: Honghe Prefecture, Yunnan Province, China, is a key area affected by HIV/AIDS. Given the high number of infected individuals, understanding HIV transmission in this region is crucial to controlling the epidemic in Yunnan Province. A molecular epidemiology study with 1004 newly diagnosed HIV-1 cases in 2022 was conducted to characterize transmission and guide targeted interventions. Of the 833 samples genotyped, nine HIV-1 genotypes were identified, with CRF08_BC (56.7%), URFs (17.8%), CRF07_BC (13.9%) and CRF01_AE (7.1%) being the most prevalent. These genotypes were widely distributed but concentrated in the center and east of the prefecture. Molecular network analysis showed varying clustering rates among counties, with Luxi County having the highest and Honghe County the lowest. Low edu

SUBMITTER: Yang H 

PROVIDER: S-EPMC11929831 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature