Magnesium oxide nanoparticles modulate phase separation to form trabecular-structured cryogels for bone defect repair.

ABSTRACT: Critical-sized bone defects pose notable therapeutic challenges and often require extensive bone grafts for effective intervention, leading to a substantial medical burden. The scarcity of autologous bone and the complex architecture of trabecular bone necessitate the development of cost-effective biomimetic graft materials. In this study, we developed a MgO nanoparticle-incorporated hydrogel scaffold (P-G-C-MgO2) using a freeze-induced phase separation approach. The scaffold achieved a porous structure with 56.48 ± 7.062 % porosity and an average pore size of 565.7 ± 53.62 μm, closely mimicking natural trabecular bone. It demonstrated exceptional mechanical stability during degradation and consistently released bioactive components, including Mg²⁺, type I collagen, and gelatin.

SUBMITTER: Liu B 

PROVIDER: S-EPMC11929891 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature