Empirical versus pre-emptive antifungal therapies for invasive fungal infections in critically ill patients.

ABSTRACT:

Background

The initiation strategy of antifungal therapy (AT) is among the most discussed practices for patients vulnerable to invasive fungal infections (IFI). In low-resource countries, there are also no appropriate consensus or guidelines for this issue. Given this clinical gap, we aimed to investigate the use of empirical and pre-emptive therapy in an Asian intensive care setting.

Methods

We conducted a retrospective cohort study (timeframe 2019-2020) on critically ill adults receiving systemic antifungals for ≥ 3 days. The exposure was empirical or pre-emptive therapy of systemic antifungals. The primary outcome was IFI-related mortality (in percentage, including in-hospital death or discharge/transfer with death prognosis). The secondary outcomes included overall ratio

SUBMITTER: Pham HT 

PROVIDER: S-EPMC11929986 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature